P-206 An evaluation of the incidence of total failed fertilization (TFF) following conventional IVF (cIVF) and the outcome of subsequent intracytoplasmic sperm injection (ICSI) cycles

Abstract Study question What is the incidence of TFF following conventional IVF (cIVF) and chance live birth in subsequent ICSI treatment cycles after TFF? Summary answer The might be higher than previously reported establishment in-house benchmarks are recommended. Treatment continuation results acceptable rates. known already a cIVF devastating outcome for patients physicians. fear this unfortunate event assumable one main drivers overutilizing ICSI. should less 5 % stimulated based on ESHREs recommended performance indicators. Data an unselected population indeed however only available from era when was not use showed rate. We investigated evaluated such at first cycle. design, size, duration A single center, retrospective chart review time period 2010-2021 done to identify all where did result least oocyte with ≥ 2 pronuclei. Also, who had more oocytes retrieved their cycle continued using as fertilization method upcoming were selected. Participants/materials, setting, methods total 5772 initiated identified electronic database examined period. Criterion normozoospermia applied 1001 (17.3%) cycles. All cases noted number oocytes, rank cycle, female age if any recorded. analyzed Chi-Square test, p < 0.05 considered significant. Main role 125 out (12.49% failed rate per cIVF). significantly frequency seen 3 compared those two (38/99 [38.38%] vs. 87/902 [9.65%], 0.001). No statistical difference detected between risk occurring first, second or third (87/664 [13.10%], 30/224 [13.39%], 5/75 [6.67%] respectively; > 0.05). differences remained non-significant (67/608 [11.02%], 16/199 [8.04%], 4/68 [5.88%] different groups similar (16/157 [10.19%], 41/362 [11.33%], 54/381 [14.17%] 14/101 [13.86%] 30, 31-35, 36-40 >40 years 56 These completed 101 resulting (3%) 75.1% (524/698) which our baseline (70.9% [25231/35568]; Nineteen these (33.9%) ended up giving continuation. Limitations, reasons caution Selection criteria, e.g. patient characteristics type PGT-A, choice probably source variation centers. It that laboratories establish own benchmark values data TFF. Wider implications findings Previous studies serum luteinizing hormone progesterone levels trigger critical predictors previous successful suggests involvement factors Acceptable rates can achieved Trial registration applicable